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XE 991 dihydrochloride

Name: XE 991 dihydrochloride
Brand: TargetMol
SKU: T17262
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T17262 Copy Product Info

Purity: 98.68%

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XE 991 dihydrochloride is a Kv7 (KCNQ) channel blocker. XE 991 dihydrochloride potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current (IC50s: 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively).

XE 991 dihydrochloride

Copy Product Info

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Catalog No. T17262

Cas No. 122955-13-9

Pack Size	Price	USA Stock	Global Stock
1 mg	$39	In Stock	In Stock
5 mg	$92	In Stock	In Stock
10 mg	$147	In Stock	In Stock
25 mg	$281	In Stock	In Stock
50 mg	$432	In Stock	In Stock
100 mg	$648	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$93	In Stock	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:98.68%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

XE 991 dihydrochloride AI Summary

XE 991 dihydrochloride exhibits varying bioactivities depending on the cell type. In HEK293T cells, it shows positive effects on cell viability with growth rates ranging from 0.32 to 0.97. Conversely, in U2OS cells, it demonstrates both positive and negative effects on cell viability, with growth rates ranging from -0.7 to 0.92. In human fibroblast cells, the compound has a more diverse impact, with growth rates ranging from -1.0 to 0.89. These findings indicate a potential cell-specific response to XE 991 dihydrochloride..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	XE 991 dihydrochloride is a Kv7 (KCNQ) channel blocker. XE 991 dihydrochloride potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current (IC50s: 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively).
Targets&IC50	Kv7.1 channel:0.75 μM, Kv7.2/Kv7.3 channel:0.6 μM, Kv7.2 channel:0.71 μM, M-current:0.98 μM

Chemical Properties

Molecular Weight	449.37
Formula	C₂₆H₂₂Cl₂N₂O
Cas No.	122955-13-9
Smiles	Cl.Cl.O=C1c2ccccc2C(Cc2ccncc2)(Cc2ccncc2)c2ccccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 12 mg/mL (26.7 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 0.5 mg/mL (1.11 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2253 mL	11.1267 mL	22.2534 mL	111.2669 mL
5 mM	0.4451 mL	2.2253 mL	4.4507 mL	22.2534 mL
10 mM	0.2225 mL	1.1127 mL	2.2253 mL	11.1267 mL
20 mM	0.1113 mL	0.5563 mL	1.1127 mL	5.5633 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc